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Ubiquinol

Background:

Coenzyme Q10 (CoQ10) is a coenzyme
present in most cell bodies of animals and is located primarily in the
mitochondria. Ubiquinol is a derivative of CoQ10 that is fully reduced and
saturated with extra electrons to assist in bodily absorbance (R). Because humans can
synthesize ubiquinol, it is not classed as a vitamin.[3]

Purpose:

CoQ10 and ubiquinol are key
components in the electron transport chain, facilitating the production of ATP
in redox reactions(R).

Why Supplement?

From Mayo Clinic

 

  • Levels of CoQ10 in
    your body decrease as you age. CoQ10 levels have also been found to be lower in
    people with certain conditions, such as heart disease.
  • CoQ10 is found in
    meat, fish and whole grains. The amount of CoQ10 found in these dietary
    sources, however, isn’t enough to significantly increase CoQ10 levels in your
    body

From SelfHacked:

 

  • Increases antioxidant
    capacity
  • Reduces oxidative
    stress before exercise and increases endothelial cell function, cell energy,
    and muscle recovery post-exercise.  (The
    Mayo Clinic notes that research in this area has produced mixed results)
  • In men, increases
    sperm count and motility

From WebMD:

 

From Ubiquinol.org

 

  • Promotes optimal heart
    health
  • Supports natural
    cellular energy production
  • Replenishes Ubiquinol
    levels depleted by aging, certain health conditions, and/or
    cholesterol-lowering medicines
  • Is more bioactive than
    Conventional CoQ10 (ubiquinone)

Dosage:

From
ConsumerLab:

 

  • Among the 44 products
    tested by ConsumerLab, the suggested daily serving size ranged from 30 mg to
    400 mg.

From
ClinicalTrials.Gov:

 

  • In a 2017 clinical
    trial, daily dosages of 600mg led to side effects vs placebo.

From SelfHacked:

 

  • Ubiquinol doses vary
    based on the type of medication taken and the reason for taking it.
  • In order to maintain
    healthy blood levels, consumers should take approximately 25-50 mg per day.
  • If consumers are
    looking to improve brain function, 150-200 mg should be taken per day.
  • When purchasing Coenzyme
    Q10 or ubiquinol for supplementation, the two ingredients needed for successful
    absorption are either BioQ10 or Ubiquinol, both in a soft gel capsule. They are
    sold as either 100 mg capsules or 300 mg capsules.

Side Effects / Adverse Events:

Side
effects are possible, especially if the patient is allergic to the supplement
ubiquinol.

 

  •    Upset Stomach
  •    Diarrhea
  •    Nausea
  •    Loss of appetite
  •    Mild insomnia
  •    Rash

Potential interactions:

Before using this product,
tell your doctor or pharmacist of all prescription and nonprescription medications you may use, especially of: drugs for high blood
pressure
, “blood thinners” (e.g., warfarin), drugs for diabetes, drugs for high cholesterol (e.g., atorvastatin, lovastatin).

CoQ10 might make
anti-coagulants (blood-thinning drugs), such as warfarin (Coumadin, Jantoven),
less effective. This could increase the risk of a blood clot.

Clinical Trials:

 

Data Sources:

 

 

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