Coenzyme Q10 (CoQ10) is a coenzyme
present in most cell bodies of animals and is located primarily in the
mitochondria. Ubiquinol is a derivative of CoQ10 that is fully reduced and
saturated with extra electrons to assist in bodily absorbance (R). Because humans can
synthesize ubiquinol, it is not classed as a vitamin.[3]


CoQ10 and ubiquinol are key
components in the electron transport chain, facilitating the production of ATP
in redox reactions(R).

Why Supplement?

From Mayo Clinic


  • Levels of CoQ10 in
    your body decrease as you age. CoQ10 levels have also been found to be lower in
    people with certain conditions, such as heart disease.
  • CoQ10 is found in
    meat, fish and whole grains. The amount of CoQ10 found in these dietary
    sources, however, isn’t enough to significantly increase CoQ10 levels in your

From SelfHacked:


  • Increases antioxidant
  • Reduces oxidative
    stress before exercise and increases endothelial cell function, cell energy,
    and muscle recovery post-exercise.  (The
    Mayo Clinic notes that research in this area has produced mixed results)
  • In men, increases
    sperm count and motility

From WebMD:


From Ubiquinol.org


  • Promotes optimal heart
  • Supports natural
    cellular energy production
  • Replenishes Ubiquinol
    levels depleted by aging, certain health conditions, and/or
    cholesterol-lowering medicines
  • Is more bioactive than
    Conventional CoQ10 (ubiquinone)




  • Among the 44 products
    tested by ConsumerLab, the suggested daily serving size ranged from 30 mg to
    400 mg.



  • In a 2017 clinical
    trial, daily dosages of 600mg led to side effects vs placebo.

From SelfHacked:


  • Ubiquinol doses vary
    based on the type of medication taken and the reason for taking it.
  • In order to maintain
    healthy blood levels, consumers should take approximately 25-50 mg per day.
  • If consumers are
    looking to improve brain function, 150-200 mg should be taken per day.
  • When purchasing Coenzyme
    Q10 or ubiquinol for supplementation, the two ingredients needed for successful
    absorption are either BioQ10 or Ubiquinol, both in a soft gel capsule. They are
    sold as either 100 mg capsules or 300 mg capsules.

Side Effects / Adverse Events:

effects are possible, especially if the patient is allergic to the supplement


  •    Upset Stomach
  •    Diarrhea
  •    Nausea
  •    Loss of appetite
  •    Mild insomnia
  •    Rash

Potential interactions:

Before using this product,
tell your doctor or pharmacist of all prescription and nonprescription medications you may use, especially of: drugs for high blood
, “blood thinners” (e.g., warfarin), drugs for diabetes, drugs for high cholesterol (e.g., atorvastatin, lovastatin).

CoQ10 might make
anti-coagulants (blood-thinning drugs), such as warfarin (Coumadin, Jantoven),
less effective. This could increase the risk of a blood clot.

Clinical Trials:


Data Sources:



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