Coenzyme Q10 (CoQ10) is a coenzyme
present in most cell bodies of animals and is located primarily in the
mitochondria. Ubiquinol is a derivative of CoQ10 that is fully reduced and
saturated with extra electrons to assist in bodily absorbance (R). Because humans can
synthesize ubiquinol, it is not classed as a vitamin.
CoQ10 and ubiquinol are key
components in the electron transport chain, facilitating the production of ATP
in redox reactions(R).
From Mayo Clinic
- Levels of CoQ10 in
your body decrease as you age. CoQ10 levels have also been found to be lower in
people with certain conditions, such as heart disease.
- CoQ10 is found in
meat, fish and whole grains. The amount of CoQ10 found in these dietary
sources, however, isn’t enough to significantly increase CoQ10 levels in your
- Increases antioxidant
- Reduces oxidative
stress before exercise and increases endothelial cell function, cell energy,
and muscle recovery post-exercise. (The
Mayo Clinic notes that research in this area has produced mixed results)
- In men, increases
sperm count and motility
- Coenzyme Q10 has been
used for heart problems (e.g., heart failure, angina), high blood
disease, gum disease, and certain diseases passed down through families (Huntington’s
dystrophy). It has also been
used for reducing the number of migraine
headaches and for reducing cell
damage that may occur after surgery or treatment with certain anti-cancer drugs
- Promotes optimal heart
- Supports natural
cellular energy production
- Replenishes Ubiquinol
levels depleted by aging, certain health conditions, and/or
- Is more bioactive than
Conventional CoQ10 (ubiquinone)
- Among the 44 products
tested by ConsumerLab, the suggested daily serving size ranged from 30 mg to
- In a 2017 clinical
trial, daily dosages of 600mg led to side effects vs placebo.
- Ubiquinol doses vary
based on the type of medication taken and the reason for taking it.
- In order to maintain
healthy blood levels, consumers should take approximately 25-50 mg per day.
- If consumers are
looking to improve brain function, 150-200 mg should be taken per day.
- When purchasing Coenzyme
Q10 or ubiquinol for supplementation, the two ingredients needed for successful
absorption are either BioQ10 or Ubiquinol, both in a soft gel capsule. They are
sold as either 100 mg capsules or 300 mg capsules.
Side Effects / Adverse Events:
effects are possible, especially if the patient is allergic to the supplement
- Upset Stomach
- Loss of appetite
- Mild insomnia
Before using this product,
tell your doctor or pharmacist of all prescription and nonprescription medications you may use, especially of: drugs for high blood
pressure, “blood thinners” (e.g., warfarin), drugs for diabetes, drugs for high cholesterol (e.g., atorvastatin, lovastatin).
CoQ10 might make
anti-coagulants (blood-thinning drugs), such as warfarin (Coumadin, Jantoven),
less effective. This could increase the risk of a blood clot.
- 20 trials at ClinicalTrials.Gov